Primary mycoses and virulence of dimorphous particularly dangerous micromycetes

Mycotic infections are traditionally considered to be markers of immunodeficiency, however, primary mycoses develop even in immunocompetent individuals. Etiological agents mycoses, which, according the nomenclature adopted Russian Federation, classified as particularly dangerous, micromycetes group II pathogenicity genera Coccidioides, Histoplasma, Paracoccidioides, Blastomyces. Particularly dangerous common certain geographical areas world: coccidioidomycosis occurs semi-desert regions, histoplasmosis and paracoccidioidomycosis – tropical areas, blastomycosis temperate climate regions. However, despite endemic nature these diseases, they remain important both for European countries Federation a number reasons, sporadic cases regularly recorded many countries. It has been shown that several genetically determined factors implementation virulent properties pathogenic fungi. Thermal dimorphism is fundamental importance trigger transformation pathogen from mycelial tissue (parasitic) growth phase, which causative agent infection able fully realize its properties.